7 Best Online Weight Loss Medications in 2025: Complete Comparison

The weight loss industry has been revolutionized by telehealth platforms offering prescription GLP-1 medications directly to your door. With monthly costs ranging from under $200 to over $1,000, finding the right provider can mean the difference between sustainable success and expensive disappointment.

After extensive research and analysis of patient experiences, we’ve identified the seven most reliable online weight loss medication services. This guide breaks down everything you need to know: pricing, medication options, support levels, and what real users experience.

What are GLP-1 Weight Loss Medications?

Weight management has been revolutionized by GLP-1 receptor agonists. Medications such as semaglutide and tirzepatide regulate appetite hormones and slow digestion. Previously, only surgery could achieve weight loss of 15-22% of body weight in clinical trials.

It’s not enough to take medication alone. Most successful programs combine pharmaceutical interventions with behavioral support, medical monitoring, and lifestyle counseling. The choice of the right provider becomes crucial in this situation.

Quick Comparison: 7 Best Online Weight Loss Medications

Provider	Starting Price	Insurance	Best Feature
#1 ShedRx	$199/mo	Coming Soon	Flexible options & guarantee
#2 Ro.co	$145/mo + meds	Yes	Insurance navigation
#3 Hims & Hers	$165/mo	No (FSA/HSA)	Oral options available
#4 GoodRx	Varies	Varies	Price comparison tools
#5 Found	Varies	Yes	Full coaching team
#6 PlushCare	$25/visit	Yes	Lowest consultation fee
#7 Henry Meds	$247/mo	No	All-inclusive pricing

7 Best Online GLP-1 Weight Loss Medications

1. ShedRx

Best for: Customizable programs with guaranteed results

Medications Available: Brand-name (Ozempic®, Wegovy®, Mounjaro®, Zepbound®) and compounded versions 

Pricing Structure: From $199/month medication-only; add $70/month for full coaching 

Insurance Status: Cash-pay currently; insurance options coming soon.

Time to Start: 24-48 hour approval process.

Why ShedRx Leads the Pack: ShedRx disrupts the one-size-fits-all model by offering true customization. Their unique approach lets you choose exactly how much support you want – from basic medication access to comprehensive lifestyle transformation programs. This flexibility, combined with their bold weight loss guarantee, sets them apart.

The ShedRx Experience: Starting is refreshingly simple. A 10-minute online assessment covers your health history, goals, and preferences. Within 24-48 hours, a licensed physician reviews your case. If approved, medications ship directly from verified pharmacies. What’s revolutionary is their oral medication options – sublingual drops and lozenges that dissolve under the tongue, eliminating injection anxiety for needle-phobic patients.

Highlights

• Industry-first satisfaction guarantee: 10% weight loss in 9 months or money back
• Alternative delivery methods beyond injections
• Modular coaching system – add or remove support as needed
• Established track record with 55,000+ successful patients
• Special introductory pricing with promotional discounts
• No long-term contracts – cancel or pause anytime

Considerations: While the flexibility is appealing, some patients might underestimate their need for support and skip coaching to save money. The current cash-only model may strain budgets, though insurance integration is reportedly launching soon.

Ideal For: Self-directed individuals who want options, or those seeking premium support at reasonable prices. Perfect for anyone who values flexibility and proven results.

2. Ro.co Body Program

Best for: Premium experience with insurance optimization

Medications Available: Brand-name only (Wegovy, Ozempic, Zepbound) 

Pricing Structure: $145 monthly membership + medication costs 

Insurance Status: Full integration with coverage optimization 

Time to Start: 2-3 days including insurance verification

Why Ro.co Excels: Ro has solved the insurance puzzle that frustrates so many patients. Their technology automatically checks your coverage, handles prior authorizations, and even appeals denials. This white-glove approach to insurance navigation justifies their premium positioning.

The Ro Experience: Upon joining, you complete a comprehensive metabolic assessment that goes beyond basic weight loss. Ro’s physicians analyze your complete health picture, creating personalized treatment protocols. Their app seamlessly integrates medication management, progress tracking, and provider communication. It feels more like having a concierge medical service than using a typical telehealth platform.

Highlights

• Dedicated insurance advocate assigned to each patient
• Proprietary metabolic profiling and tracking
• Direct pharmacy partnerships preventing stockouts
• Integrated lab ordering with home collection kits
• Real-time medication availability updates
• Premium app experience with health insights

Considerations: The $145 monthly fee isn’t covered by insurance, creating an additional expense. Limited to brand-name medications means potential supply issues and higher costs even with insurance.

Ideal For: Patients with comprehensive insurance wanting a premium, hassle-free experience. Best for those who value convenience over cost savings.

3. Hims & Hers

Best for: Discrete, consumer-friendly weight loss solutions

Medications Available: Widest variety, including oral compounds 

Pricing Structure: From $69/month (oral) to $299/month (injectables) 

Insurance Status: Not accepted; FSA/HSA eligible 

Time to Start: Same-day consultations available

Why Hims & Hers Stands Out: By applying their successful telehealth model to weight loss, Hims & Hers created the most approachable platform available. They’ve eliminated the clinical feel while maintaining medical legitimacy, making weight loss medication feel as normal as ordering vitamins online.

The Complete Package: The journey starts with a photo-based consultation – no video calls required. Their providers review your information and create personalized treatment plans within hours. What’s groundbreaking is their oral GLP-1 compounds, offering the same active ingredients in tablet form. Monthly supplies arrive in discrete packaging, and you communicate with providers via text whenever needed.

Highlights

• The only major platform with oral GLP-1 alternatives at scale
• Sublingual tablets dissolve quickly, no water needed
• Personalized compound formulations are adjusted monthly
• Integration with mental health support for emotional eating
• Discrete billing and packaging for privacy
• 24/7 provider access via messaging

Considerations: Without insurance acceptance, costs can add up quickly for those wanting brand-name medications. The consumer-focused approach might feel too casual for patients preferring traditional medical relationships.

Ideal For: Anyone prioritizing convenience and privacy, especially those avoiding injections. Perfect for busy professionals wanting discreet, accessible care.

4. GoodRx Care

Best for: Price-conscious comparison shoppers

Medications Available: All FDA-approved options through the network 

Pricing Structure: Varies widely by provider and location 

Insurance Status: Depends on selected provider 

Time to Start: 1-5 days, depending on provider choice

Why GoodRx Works: Instead of being a provider themselves, GoodRx created a transparent marketplace connecting patients with multiple options. This unique model empowers consumers to find the best combination of price, convenience, and service for their specific situation.

The Marketplace Advantage: Enter your location and preferences to see all available providers, their prices, wait times, and patient ratings. GoodRx displays everything transparently – consultation fees, medication costs, and even estimated insurance coverage. Once you choose a provider, they facilitate the connection while continuing to monitor prices across pharmacies for the best deals.

Highlights

• Complete price transparency before committing
• Access to exclusive pharmacy discounts and coupons
• Real patient reviews and provider ratings
• Price tracking alerts for medication savings
• Works with telehealth and traditional providers
• Comparison tools showing total monthly costs

Considerations: The marketplace model means experiences vary significantly between providers. Requires more research and decision-making effort from patients compared to direct services.

Ideal For: Savvy consumers who enjoy comparison shopping and want the absolute best value. Perfect for those comfortable navigating options independently.

5. Found

Best for: Comprehensive behavioral transformation

Medications Available: Brand-name and proprietary compounds 

Pricing Structure: Program fees vary; medications are billed separately 

Insurance Status: Accepted for medications only 

Time to Start: 5-7 days after comprehensive assessment

Why Found Differs: Found approaches weight loss as a complex behavioral and medical challenge requiring multiple interventions. Their proprietary assessment system creates highly personalized plans addressing root causes, not just symptoms.

The Transformation Journey: Found’s process begins with their extensive MetabolicPrint™ assessment – a deep dive into your genetics, psychology, lifestyle, and medical history. You’re then matched with a complete care team: a prescribing physician, registered dietitian, and behavioral coach. Weekly group sessions provide community support while individual coaching keeps you accountable.

Highlights

• Proprietary metabolic typing system for personalization
• Complete care team with multiple specialists
• Science-based curriculum addressing behavior change
• Community support through group coaching
• Prescription combinations tailored to metabolic type
• Lifetime access to educational resources

Considerations: The intensive approach requires significant time investment – expect multiple appointments and assignments weekly. Some find the psychological focus overwhelming if they’re just seeking medication.

Ideal For: Those ready for a complete lifestyle overhaul with professional guidance. Best for people who’ve struggled with yo-yo dieting and want lasting change.

6. PlushCare

Best for: Straightforward medical care without extras

Medications Available: All major options, including compounds 

Pricing Structure: $25 per visit; medications via insurance 

Insurance Status: Accepted for consultations and prescriptions 

Time to Start: Same-day appointments are often available

Why PlushCare Appeals: Sometimes, simple is better. PlushCare offers traditional medical care through modern technology – no apps, programs, or coaching required. Just straightforward access to prescription weight loss medications through licensed physicians.

The Basic Approach: Book an appointment online, often available same day. During your video consultation, discuss your weight loss goals with a board-certified physician. If appropriate, they’ll prescribe GLP-1 medications and send prescriptions to your preferred pharmacy. Follow-up appointments happen as needed, typically monthly.

Highlights

• Lowest consultation fees industry-wide
• No membership or program fees
• Simple insurance billing process
• Can address multiple health concerns
• Established physicians with ongoing relationships
• Traditional medical record keeping

Considerations: Minimal support between appointments means self-directed management. No specialized weight loss resources, apps, or coaching programs included.

Ideal For: Experienced patients wanting prescription access without programs. Perfect for those with good insurance preferring traditional doctor relationships.

7. Henry Meds

Best for: Budget-friendly all-inclusive pricing

Medications Available: Proprietary compound formulations only 

Pricing Structure: $247/month includes everything 

Insurance Status: Not accepted – cash only 

Time to Start: 24-48 hours from consultation

Why Henry Meds Satisfies: In a market full of hidden fees and complex pricing, Henry Meds offers refreshing transparency. One monthly price covers everything – consultations, medications, shipping, and support. No surprises, no add-ons, no insurance hassles.

The Simplified Process: Start with a free consultation to determine eligibility. If approved, choose your payment plan and receive medications monthly. Their proprietary compounds often include B-vitamins and other supplements to minimize side effects. Cancel or pause anytime without penalties or fees.

Highlights

• True all-inclusive pricing with no hidden costs
• Free initial consultation – pay only if approved
• Proprietary formulations to reduce side effects
• Flexible payment plans and financing options
• No commitment required – cancel anytime
• Both injectable and oral options available

Considerations: Limited to compounded medications only – no access to brand names. Without insurance options, long-term costs might exceed other providers for some patients.

Ideal For: Budget-conscious individuals wanting predictable costs. Perfect for those without insurance or preferring transparent, straightforward pricing.

Bottom Line

ShedRx stands out for its flexibility – choose exactly the support level you need while accessing both brand-name and compounded medications. Their weight loss guarantee and established track record make them a safe choice for most people. For insurance users, Ro.co and PlushCare offer the smoothest experience. Budget-conscious buyers should consider Henry Meds for transparent pricing or GoodRx for comparison shopping.